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A Study on Epidemiological Characteristics of Nosocomial Infection in Korea.
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Joung Soon Kim, Sung Eun Lee
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Korean J Epidemiol. 1995;17(2):137-155.
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 Abstract
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Abstract
In Korea, the nosocomial infection control program is not well estabilished. This study was carried out to investigate the incidence rate of nosocomial infection occurred among patients of 18 hospitals for 7 days ; cases of hospital infection per 10,000 patients discharged during the same period in Korea. The study was done in 18 volunteer hospitals and nosocomial infection cases for 7 days were collected retrospectively. The result was as follows; 1. The incidence rate of nosocomial infection for 7 days was 578 cases per 10, 000 patients discharged. 2. Pneumonia was the most prevalent nosocomial infection ; the incidence rate 112.7 cases per 10,000 discharges. The incidence rate of urinary tract infection was 85. 7 cases and that of septicemia was 36. 7 cases per 10, 000 discharges. 3. The incidence rate of nosocomial infection among patients of neurosurgery department was the highest(2,742 cases per 10,000 discharges). And the incidence rate of nosocomial infection was 6 times higher among the patients of intensive care unit than that of general ward. The reasons of higher nosocomial infection rate of intensive care unit and neurosurgery appeared to be due to many invasive procedures.
Thus the priority in nosocomial infection control program must be given to those groups.
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Summary
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An epidemiologic study on sudden unknown fever in intravenous therapy
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Sung Eun Lee, Kang Won Choi
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Korean J Epidemiol. 1987;9(2):217-227.
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There was a sudden unknown fever related to IV therapy in a university Hospital from Aug. to Sep. 1986. This study tries to survey epidemiological feature of sudden fever and to investigate the cause of sudden fever.
The results were as follows;
1) There was 55 cases of unknown fever related to IV therapy. The incidence rate was 2 persons per 1,000 inpatients, 29.3 persons per 1,000 discharges, 2.1 persons per 1,000 IV fluids, 3.2 persons per 1,000 IV devices and 2.5 persons per 1,000 IV sets.
2) To confirm this episode as epidemic, follow-up study was done in 2 general surgery nursing units from Aug. to Sep. 1987, in which there had been 26 cases of unknown fever in 1986. There was no case of sudden fever in follow-up study.
3) The pattern of this sudden fever was chill (55 cases), fever over 38°C (45 cases), neurologic sign (4 cases) and gastro-intestinal sign (5 cases). In 26 cases (47.2%), the onset of the fever was within 1 hour after starting of IV therapy. And in 29 cases (52.7%), the fever was developed within 100 cc or less infusion.
4) To confirm the cause, microbiological culture and pyrogen test were done. In 12 microbiological cultures, there was one positive (the microorganism was S. epidermis) and in 25 pyrogen tests, one pyrogen test was found out positive.
5) To prevent such episode, active hospital infection control program is recommended in each hospital and a positive national supervision on medical equipments should be necessary.
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Summary
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An epidemiology study on nosocomial infection of an university hospital in Seoul
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Sung Eun Lee, Joung Soon Kim
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Korean J Epidemiol. 1986;8(1):147-173.
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Abstract
Nosocomial infection has become a problem of public health in medical cost and health problem. We have no incidence rate data in Korean.
So this study tries to survey epidemiological feature of nosocomial infection in a university hospital. From November 1985 to January 1986, this study was done.
The result was as follows;
1) The incidence rate of nosocomial infection was 576.7 persons per 10,000 discharges. The incidence rate of nosocomial infection by type of infection was that urinary tract infection was 143.4 cases and respiratory infection was 117.2 cases and post operative wound infection was 84.8 cases per 10,000 discharges.
In internal medicine, respiratory infection was 25.7% of total nosocomial infection. In general surgery, post operative wound infection was 24.1% of total nosocomial infection.
The causal micro-organisms of nosocomial infection were Pseudomonas(16.1%), E. coli(13.7%), Staphylococcus(14.7%), Serratia(7.1%) and etc. The total resistance of micro-organism which caused nosocomial infection, was 62.4% for 13 types of antibiotics.
2) The risk factor of nosocomial infection was tested by comparison of two groups, with hospital infection and without hospital infection. The duration of hospitalization was appeared very significant risk factor of nosocomial infection (X2 = 211.6**). The medical diagnosis was also appeared a significant risk factor(X2=45.7**) and medical speciality leaded the same result(X2 = 95.3**).
3) The total time of surveillance for nosocomial infection was 4.75 hours per day in hospital of 1,200 beds. It was only time for chart review and microbiological finding. For manpower study, it is requested that time for patient visiting and miscellaneous time.
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Summary
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Chromosome aberration and glutathio -S- transferase activitiy in peripheral lymphocytes of workers exposed to ethylene oxide.
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Jin Sook Kim, Sung Eun Lee, Hai Won Chung
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Korean J Epidemiol. ;15(2):212-221.
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Abstract
This study was undertaken to compare the frequency of chromosome aberrations and Glutathion -S- Transferase activity in peripheral lymphocytes between workers exposed to ethylene oxide and control group.
Chromosome aberrations were analyzed in 200cells per sample after culture for 48-51hrs.
The results obtained were as follows:
1. The overall frequencies of cells with chromosome aberration were 1.8% in the exposed group and 0.9% in the control group. And the overall level of GST activity was 8.39 I.U in the exposed group and 7.99 I.U in the control group.
2. In the control group, It was found that significant increase in chromosome aberrations was associated with increasing age, but GST activity was not correlated with age.
3. For the exposed group, significant increase in chromosome aberration was observed among the workers working under poor ventilation compared to those under good ventilation. The frequencies of cells with chromosome aberration were 1.3% among the workers under good ventilation, 2.0% under poor ventilation and 2.7% under no ventilation. GST activity was not, however, correlated with the types of ventilation of the working environment.
From above results, it is suggested that the exposure to ethylene oxide increased the frequency of chromosome aberration and the level of GST activity, but there was no significant correlation between the frequency of chromosome aberration and level of GST activity.
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